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Human neuronal cells migrate toward sites of damage, where neighboring astrocytes up-regulate the inflammatory SDF-1 [88]

349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

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These effects are transient and resolve quickly under clinical supervision